JAK2-STAT5 signaling
نویسندگان
چکیده
منابع مشابه
JAK2-STAT5 signaling
A recent article published by Britschgi et al. in Cancer Cell, "JAK2/STAT5 Inhibition Circumvents Resistance to PI3K/mTOR Blockade: A Rationale for Cotargeting These Pathways in Metastatic Breast Cancer," describes a positive feedback loop of JAK2/STAT5 activation that drives resistance to PI3K/mTOR inhibition in breast cancer. The authors found that genetic or pharmacological inhibition of JAK...
متن کاملDivision of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range
Cellular signal transduction is governed by multiple feedback mechanisms to elicit robust cellular decisions. The specific contributions of individual feedback regulators, however, remain unclear. Based on extensive time-resolved data sets in primary erythroid progenitor cells, we established a dynamic pathway model to dissect the roles of the two transcriptional negative feedback regulators of...
متن کاملJAK2-STAT5 signaling: A novel mechanism of resistance to targeted PI3K/mTOR inhibition
The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters. A Frank. 2013. " JAK2-STAT5 signaling: A novel mechanism of resistance to targeted PI3K/mTOR inhibition. " JAK-STAT 2 (4): e24635.
متن کاملProlactin regulates ZNT2 expression through the JAK2/STAT5 signaling pathway in mammary cells.
The zinc transporter ZnT2 (SLC30A2) plays an important role in zinc secretion into milk during lactation. The physiological process of mammary gland secretion is regulated through complex integration of multiple lactogenic hormones. Prolactin plays a primary role in this regulation through the activation of various signaling cascades including Jak2/STAT5, mitogen-activated protein kinase (MAPK)...
متن کاملHigh-dimensional Bayesian parameter estimation: case study for a model of JAK2/STAT5 signaling.
In this work we present results of a detailed Bayesian parameter estimation for an analysis of ordinary differential equation models. These depend on many unknown parameters that have to be inferred from experimental data. The statistical inference in a high-dimensional parameter space is however conceptually and computationally challenging. To ensure rigorous assessment of model and prediction...
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ژورنال
عنوان ژورنال: JAK-STAT
سال: 2013
ISSN: 2162-3996
DOI: 10.4161/jkst.24635